MSU the Gene Ar Encodes Paper

Description

Part A) The gene AR that encodes an androgen receptor (that is

required for cells and tissues to respond to androgen hormones), is located on the X

chromosome. A recessive nonsense mutation in this gene leads to complete androgen

insensitivity syndrome, which means that the body cannot use androgens at all. If a XY

individual is born and they inherit the nonsense mutation form of AR, (assume a

functional copy of SRY on their Y) with regard to sexual determination, should this

individual develop with more female or male phenotypic characteristics? Why?

Part B) In a pedigree for this trait, what would be unusual about the pedigree and the affected

individuals given that this trait is X-linked and recessive? (As a note, pedigrees display

individuals as their phenotypic biological sex rather than by chromosome makeup)

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